1. Provide a reasonable mechanism for the reactions shown below, using the
rhodium complex shown. Make sure to show how all of the products are made
as well as labeling the name of each step as it occurs. Your reaction does not
need to be absolutely correct to receive full credit but it should make chemical
sense.
a)
b)
2. One challenge for potential drugs is the ability for the molecule to evade the
bodyʼs defenses against foreign compounds. When a defense mechanism is
activated, the compound or drug can be released from the body as waste, often
after having been metabolized, somehow, to aid in excretion. Ibuprofen, for
example, is often metabolized by cytochrome P450 enzymes in the body similar
to camphor. Please answer the following questions about drug metabolism by
cytochrome P450.
Ni
Ph3P
Ph3P
PPh3
H
a) Of the hydrogens shown in ibuprofen, which site is more likely to be oxidized
by cytochrome P450. Explain very clearly why one is more likely than the other.
(Hint: Think about camphor oxidation in P450cam)
b) Show the mechanism by which this oxidation of ibuprofen occurs.
3. You are a senior student graduating from the Chemistry department
and you have landed a job with the CIA. Sweet!!
On your first day you are assigned to a super secret project involving the use of
artificial blood. They want to create artificial blood with different oxygen
transporters to allow their “special agents” to breathe underwater. You are in
charge of designing one of the oxygen transporters. Draw the active site of the
oxygen transporter and explain how would you get this transporter.
Hint: on land and in oceans you might find what you are looking for. (Remember
this is the CIA, they talk with cryptic messages)
4. In 5 sentences or less, discuss why cisplatin is used to fight cancer, but the
trans- derivative has no anti-cancer function.
CH3
COOH
H
H
H3C
CH3
Place your order now for a similar paper and have exceptional work written by our team of experts to guarantee you A Results

Why Choose US   

    6+ years experience on custom writing
    80% Return Client
    Urgent 2 Hrs Delivery
    Your Privacy Guaranteed
    Unlimited Free Revisions