Horsetail is a bizarre looking kind of plant with crawling, string like rootstock and roots at the hubs that produce various empty stems. Phytochemically, the plant is found to have a wide cluster of optional metabolites which add to the restorative properties of the plant. The plant Equisetum arvense is a society medication and its concentrate is utilized locally to treat tuberculosis, edema, kidney and bladder stones, urinary parcel diseases, incontinence, sharpness and dyspepsia, ulcers and wounds, draining and so on. Reports are accessible with respect to its mitigating, antinociceptive (Monte Do et al., 2004), cell reinforcement and antiproliferative (Dragana et al., 2010), antimicrobial (Fathi et al., 2004), hepatoprotective (Goodness et al., 2004), antidiabetic (Safiyeh et al., 2007), coagulant and astringent properties (Clute, 1928). Horsetail is primarily utilized as a diuretic (Jung et al., 1999). The antiquated Greeks involved horsetail in the treatment of wounds. Mutagenicity/antimutagenicity measures have been utilized to recognize potential antimutagens and anticarcinogens giving open doors to the advancement of new medications to be utilized in the anticipation and treatment of neoplasies (Gebhart, 1992). Among the bioassays to survey DNA harm in mammalian cells in vivo, the chromosomal variation test is a successful momentary examine in light of the fact that the occurance of the chromosomal distortions is one of the main natural result of openness of a living being to the genotoxic specialist. In vivo mammalian chromosomal variation test has been effectively utilized for the discovery of underlying distortions prompted by the test substance in the bone marrow cells of creatures, generally rodents (Preston et al., 1987; Amer et al., 2002; Patlolla and Tchounwou, 2005). The upsides of the CA examine are connected with the phone by cell approach, an exact ID of all the different chromosome transformation types, a potential co-location of mitotic records and the semi robotized scoring by picture examination. In ongoing many years, enhancements in malignant growth treatment have emphatically expanded the endurance rates among patients (UNSCEAR, 2000). In any case, the therapies like radiotherapy and chemotherapy are possibly genotoxic and mutagenic which can prompt the advancement of auxiliary, therapy related conditions, including further tumors, as well as incline survivors toward different non-dangerous sicknesses that can frequently appear in the posterity (Glades et al., 2009). Present chemotherapy disease medicines have ended up being insufficient because of their poisonousness as well as for the cells creating obstruction (Mc Whirter et al., 1996). Concentrates on carried on mice have likewise demonstrated the way that openness to anticancer medications can result in transgenerational genomic unsteadiness (Glen and Dubrova, 2012). Chemotherapy disease treatment cases include constant utilization of antineoplastic specialists which kill neoplastic tissue as they are poisonous to quickly multiplying cells. Anyway all the while, they can harm ordinary multiplying cells also. This brings down their remedial record. Consequently long haul utilization of these antineoplastic specialists has turned into a subject of expanding concern (Arif et al., 2009). In excess of 100 chemotherapy drugs are utilized in malignant growth treatment, either alone or in mix with different medications or medicines. One such medication is Cyclophosphamide. Cyclophosphamide (CPA) which has a place with the class of oxazaphosphorines is an alkylating specialist. It had been recorded as one of the m>