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J.D. is a 37 years old white woman who presents to her gynecologist complaining of a 2-month history of intermenstrual bleeding, menorrhagia, increased urinary frequency, mild incontinence, extreme fatigue, and weakness. Her menstrual period occurs every 28 days and lately there have been 6 days of heavy flow and cramping. She denies abdominal distension, back-ache, and constipation. She has not had her usual energy levels since before her last pregnancy.

Past Medical History (PMH):
Upon reviewing her past medical history, the gynecologist notes that her patient is a G5P5with four pregnancies within four years, the last infant having been delivered vaginally four months ago. All five pregnancies were unremarkable and without delivery complications. All infants were born healthy. Patient history also reveals a 3-year history of osteoarthritis in the left knee, probably the result of sustaining significant trauma to her knee in an MVA when she was 9 years old. When asked what OTC medications she is currently taking for her pain and for how long she has been taking them, she reveals that she started taking ibuprofen, three tablets each day, about 2.5 years ago for her left knee. Due to a slowly progressive increase in pain and a loss of adequate relief with three tablets, she doubled the daily dose of ibuprofen. Upon the recommendation from her nurse practitioner and because long-term ibuprofen use can cause peptic ulcers, she began taking OTC omeprazole on a regular basis to prevent gastrointestinal bleeding. Patient history also reveals a 3-year history of HTN for which she is now being treated with a diuretic and a centrally acting antihypertensive drug. She has had no previous surgeries.

Case Study Questions

Name the contributing factors on J.D that might put her at risk to develop iron deficiency anemia.
Within the case study, describe the reasons why J.D. might be presenting constipation and or dehydration.
Why Vitamin B12 and folic acid are important on the erythropoiesis? What abnormalities their deficiency might cause on the red blood cells?
The gynecologist is suspecting that J.D. might be experiencing iron deficiency anemia.
In order to support the diagnosis, list and describe the clinical symptoms that J.D. might have positive for Iron deficiency anemia.
If the patient is diagnosed with iron deficiency anemia, what do you expect to find as signs of this type of anemia? List and describe.
Labs results came back for the patient. Hb 10.2 g/dL; Hct 30.8%; Ferritin 9 ng/dL; red blood cells are smaller and paler in color than normal. Research list and describe for appropriate recommendations and treatments for J.D.
Cardiovascular
Mr. W.G. is a 53-year-old white man who began to experience chest discomfort while playing tennis with a friend. At first, he attributed his discomfort to the heat and having had a large breakfast. Gradually, however, discomfort intensified to a crushing sensation in the sternal area and the pain seemed to spread upward into his neck and lower jaw. The nature of the pain did not seem to change with deep breathing. When Mr. G. complained of feeling nauseated and began rubbing his chest, his tennis partner was concerned that his friend was having a heart attack and called 911 on his cell phone. The patient was transported to the ED of the nearest hospital and arrived within 30 minutes of the onset of chest pain. In route to the hospital, the patient was placed on nasal cannula and an IV D5W was started. Mr. G. received aspirin (325 mg po) and 2 mg/IV morphine. He is allergic to meperidine (rash). His pain has eased slightly in the last 15 minutes but is still significant; was 9/10 in severity; now7/10. In the ED, chest pain was not relieved by 3 SL NTG tablets. He denies chills.

Case Study Questions

For patients at risk of developing coronary artery disease and patients diagnosed with acute myocardial infarct, describe the modifiable and non-modifiable risk factors.
What would you expect to see on Mr. W.G. EKG and which findings described on the case are compatible with the acute coronary event?
Having only the opportunity to choose one laboratory test to confirm the acute myocardial infarct, which would be the most specific laboratory test you would choose and why?
How do you explain that Mr. W.G temperature has increased after his Myocardial Infarct, when that can be observed and for how long? Base your answer on the pathophysiology of the event.
Explain to Mr. W.G. why he was experiencing pain during his Myocardial Infarct. Elaborate and support your answer.

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Sample Answer

 

 

 

This is a complex medical case study. Let’s break down each section and answer the questions thoroughly.

J.D.’s Case: Iron Deficiency Anemia

  1. Contributing Factors for Iron Deficiency Anemia:

    • Menorrhagia: Heavy menstrual bleeding leads to significant iron loss.
    • Multiple Pregnancies: Repeated pregnancies deplete iron stores, especially when closely spaced.
    • Recent Delivery: Postpartum blood loss and the demands of lactation further deplete iron reserves.
    • Ibuprofen Use: Long-term NSAID use can cause gastrointestinal bleeding, contributing to iron loss.

Full Answer Section

 

 

 

 

 

  1. Constipation and Dehydration:

    • Ibuprofen: NSAIDs can affect kidney function and potentially lead to dehydration.
    • Diuretic: Her antihypertensive diuretic medication can cause dehydration, which can lead to constipation.
    • Menorrhagia: Heavy blood loss can contribute to dehydration.
    • Iron Supplements: If she were taking iron supplements, these can cause constipation.
  2. Vitamin B12 and Folic Acid in Erythropoiesis:

    • Vitamin B12: Essential for DNA synthesis and red blood cell maturation. Deficiency impairs DNA synthesis, leading to macrocytic anemia (large, immature red blood cells).
    • Folic Acid: Also crucial for DNA synthesis and red blood cell maturation. Deficiency results in macrocytic anemia similar to B12 deficiency.
    • Abnormalities: Deficiencies cause megaloblastic anemia, characterized by large, fragile red blood cells with shortened lifespans.
  3. Clinical Symptoms of Iron Deficiency Anemia:

    • Fatigue and Weakness: Due to reduced oxygen-carrying capacity.
    • Intermenstrual Bleeding and Menorrhagia: Contributing to iron loss.
    • Increased Urinary Frequency and Mild Incontinence: Can be related to pelvic congestion and hormonal changes.
    • Pale Skin: Due to reduced hemoglobin.
    • Headaches and Dizziness: From reduced oxygen to the brain.
  4. Signs of Iron Deficiency Anemia:

    • Pallor: Pale skin, conjunctiva, and mucous membranes.
    • Tachycardia: Rapid heart rate to compensate for reduced oxygen.
    • Tachypnea: Rapid breathing to increase oxygen intake.
    • Koilonychia: Spoon-shaped nails.
    • Glossitis: Inflammation of the tongue.
  5. Recommendations and Treatments:

    • Iron Supplementation: Oral iron supplements (ferrous sulfate, ferrous gluconate) are the first-line treatment.
    • Dietary Changes: Increase iron-rich foods (red meat, leafy greens, fortified cereals).
    • Address Underlying Causes: Treat menorrhagia (hormonal therapy, surgery if needed).
    • Monitor for GI Bleeding: Due to NSAID use.
    • Vitamin C: Take with iron supplements to increase absorption.
    • Monitor Hb, Hct, and Ferritin: To assess treatment response.

Mr. W.G.’s Case: Acute Myocardial Infarction (AMI)

  1. Risk Factors for Coronary Artery Disease and AMI:

    • Non-Modifiable:
      • Age: Increased risk with advancing age.
      • Male gender: Men have a higher risk than premenopausal women.
      • Family history: Genetic predisposition.
      • Race.
    • Modifiable:
      • Smoking: Damages blood vessels.
      • Hypertension: Increases workload on the heart.
      • Hyperlipidemia: High cholesterol leads to plaque formation.
      • Diabetes mellitus: Damages blood vessels.
      • Obesity: Increases strain on the heart.
      • Sedentary lifestyle: Lack of exercise increases risk.
      • Stress.
  2. EKG Findings and Compatible Symptoms:

    • EKG: Expect to see ST-segment elevation, T-wave inversion, or Q waves, indicating myocardial injury.
    • Compatible Symptoms:
      • Crushing sternal chest pain radiating to the neck and jaw.
      • Nausea.
      • Pain not relieved by NTG.
      • These are all classic signs of an AMI.
  3. Most Specific Laboratory Test:

    • Cardiac Troponin: This is the most specific and sensitive marker for myocardial damage. Troponin levels rise within a few hours of an AMI and remain elevated for several days.
  4. Increased Temperature After AMI:

    • Pathophysiology: Myocardial necrosis triggers an inflammatory response. This causes the release of cytokines, which lead to fever.
    • Observation: Temperature elevation typically occurs within 24-72 hours after the AMI.
    • Duration: The fever usually lasts for a few days (3-7 days).
  5. Pain During AMI:

    • Explanation: The pain is due to myocardial ischemia (lack of blood flow) caused by coronary artery occlusion.
    • Pathophysiology:
      • Reduced blood flow leads to oxygen deprivation of the heart muscle.
      • Ischemia causes the release of chemicals (e.g., bradykinin, histamine) that stimulate pain receptors.
      • The pain is often described as crushing, squeezing, or heavy, and can radiate to the left arm, neck, or jaw.
      • The pain is caused by the heart muscle itself not receiving enough oxygen, and the nerves in the heart reacting to that lack of oxygen.

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