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What do they say about other historiansâ arguments? Who do they agree/disagree with, and why? [This is where historians position themselves with regard to the historiography or the secondary literature and say how their argument contributes to existing debates or raises new questions or approaches]. What evidence/sources is the author drawing upon? What kind of material is this? Imagery, textual, artefacts? What do you find convincing about the article and why? What do you find unconvincing about the article and why?This is the most important section. This is where you show your critical reading and critical analysis of the article. Does the author manage to persuade you of their argument? Do the ways in which they use the evidence to substantiate (back up) their argument work well or not? Telle me what you think, but make sure you back this up with evidence from the article
Sample Solution
bsorption [94, 95]. Enteric coating materials are polymers, which have acid groups. In the acidic medium of the stomach the acid groups are nonionized, and the coating material is insoluble. Fast dissolution and drug release take place in the upper intestine as a function of pH change in the environment. The polymer acid groups are ionized at higher pH and the material dissolves [95]. Cellulose acetate phthalate (CAP) was the first synthetic polymer described in 1937, which gained soon high popularity as a gastric resistant polymer. Later polyvinyl acetate phthalate (PVAP) and hydroxypropyl methylcellulose phthalate (HPMCP) were preferred, because of their lower permeability in the gastric fluid and improved stability against hydrolysis. Today the methacrylate copolymers Eudragit® L and S are two of the most widely used polymers for this purpose. The drug release from the pH-sensitive nanoparticles follows certain mechanisms which include: 1- Drug burst releases when the nanoparticle carriers dissolve at specific pH conditions: They usually exhibited burst release profiles because of the dissolution characters of the carriers; drug release from conventional nanoparticles was mainly by diffusion. For pH- sensitive nanoparticles, at low pH, the nanoparticles prepared from polycarboxylic acid were solid matrix encapsulating drug, little drug released. As they reach the small intestine, the pH changes from acidic to neutral (6â7.4), carboxylic acid groups deprotonated, the linear polymers dissolved and drugs released rapidly.>
bsorption [94, 95]. Enteric coating materials are polymers, which have acid groups. In the acidic medium of the stomach the acid groups are nonionized, and the coating material is insoluble. Fast dissolution and drug release take place in the upper intestine as a function of pH change in the environment. The polymer acid groups are ionized at higher pH and the material dissolves [95]. Cellulose acetate phthalate (CAP) was the first synthetic polymer described in 1937, which gained soon high popularity as a gastric resistant polymer. Later polyvinyl acetate phthalate (PVAP) and hydroxypropyl methylcellulose phthalate (HPMCP) were preferred, because of their lower permeability in the gastric fluid and improved stability against hydrolysis. Today the methacrylate copolymers Eudragit® L and S are two of the most widely used polymers for this purpose. The drug release from the pH-sensitive nanoparticles follows certain mechanisms which include: 1- Drug burst releases when the nanoparticle carriers dissolve at specific pH conditions: They usually exhibited burst release profiles because of the dissolution characters of the carriers; drug release from conventional nanoparticles was mainly by diffusion. For pH- sensitive nanoparticles, at low pH, the nanoparticles prepared from polycarboxylic acid were solid matrix encapsulating drug, little drug released. As they reach the small intestine, the pH changes from acidic to neutral (6â7.4), carboxylic acid groups deprotonated, the linear polymers dissolved and drugs released rapidly.>
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