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Analysis and interpretation of data (TOTAL 70%)



Q1. Read the following case study and answer the questions:


An 8-year-old boy, Jonathan Davies, who was previously in good health, noticed that he is increasingly thirsty in the last few months. He gets up many times at night to urinate and is frequently thirsty. Although his food intake has almost doubled, he has lost four pounds in the last month. He visits his GP after feeling nauseated, with vomiting on few occasions, in the last three days. The doctor’s examined his blood and urine. His blood glucose level was 30.3 mmol/L (typically 4.0 to 5.9 mmol/L and blood pH 7.13 (typically 7.36 to 7.44). His urine tested positive for acetone/acetoacetate.



(a). With specific reference to the patient data, indicate which patient is most likely to be this 8-year-old boy and explain why this is likely to be the case.

(50 words) (5 marks)



(b). Relate the elevated blood-glucose level to the actions of insulin.

(50 words) (5 marks)



(c). Relate the drop in blood pH to metabolic disturbance taking place in the liver.                                                                       (100 words) (10 marks)



(d). Explain why Jonathan is frequently thirsty.

(50 words) (5 marks)



(e). Poorly controlled Type 1 diabetes leads to numerous long term consequences.  Discuss how hyperglycemia leads to diabetic nephropathy.

(150 words) (15 marks)


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