This is a Medical School Epidemilogy Assignment.
Task begins with one paper that is flawed (despite being published in the Lancet)and we are meant to pull it apart with a focus on the appropriateness of research methods used in the study, data validity and its relevance to the objectives of the study stats used in the analysis and the interpretation therein.
The paper is Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N, et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet (London, England). 2006;368(9541):1096-105.
Critically appraise the study, outlining the study type and methodology used
How do the researchers address potential limitations, confounders and bias-identify techniques used/not used to control those biases (5)
Ethical considerations (5)
Summarise the findings and limitations of three important epidemiological studies that preceded the chosen articles. Comment on applicability, originality and importance of the literature
Explain and justify why you consider these three studies to be the most important
*the drug has been found to have severe side-effects including increased risk of heart attack. That probably needs to be a big focus here.
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