Other related References are included on the last pages and I attached some of them as well please find the others by yourself ..no outside references will be accepted in this project

PLEEEEEEEEEEEASE READ ALL REFERENCES AND
WRITE THE RELEVANT AND IMPORTANT INFORMATION ONLY IN BRIEF AND COMPLETE UNDERSTANDING THAT
THIS RESEARCH REQUIRE.

IF YOU DO NOT HAVE EXPEIRENCE OR NOT QUALIFIED PLEASE INFORM THE SUPPORT TEAM TO BE CHANGED
ASAP.

Please support the lit review with essential images AND diagrams

REGARDS,

Spinal cord anatomy in human and mouse briefly please particularly LUMBAR REGION
1-external structure INBRIEF
2-internal structure INBRIEF

WHITE MATTER
GREY MATTER
Tracts ascending and descending overview

Spinal cord diseases in general

This is just a sample
Spinal cord diseases comprise a heterogeneous category of conditions that result from damage or dysfunction of the spinal cord. The conditions can be infectious, inflammatory or vascular with their impact on the meninges and their surrounding spaces. Most of the diseases lead to paralysis since the spinal cord serves the primary function of ensuring muscle function in various effector organs by transmitting impulses from the brain. Some of the diseases include multiple sclerosis, amyotrophic lateral sclerosis (ALS), lupus, spinal Bifida, Spinal stenosis, syringomyelia (SM) and transverse myelitis. Multiple sclerosis damages the insulating cover of the nerve cells, the myelin. As a result, the communication system in the nerves disrupts.

Multiple Sclerosis (MS) overview and background IN GENERAL BRIEFLY and focus on lumber spine
Why lumbar spine in particular because it is the place of neuropathic pain.

Please see this article for complete information about EAE+LUMBAR SPINAL
Article is Establishment and characterization of an optimized mouse model
of multiple sclerosis-induced neuropathic pain using behavioral,
pharmacologic, histologic and immunohistochemical methods

Multiple Sclerosis of spinal cord
MS of the spinal cord is a demyelinating disease that affects the spinal cord. Most patients who have MS experience it in the spinal cord. Notably, the cervical spinal cord is more likely to be involved than the lower areas (Hendrix, et.al., 2015 p.93). MS of the spinal cord normally exhibits >= 1 foci of increased signal on T2- weighted images with or without a decrease in the signal in the spinal cord on T1-weighted images. In the earlier stages, the images show cord edema and swelling. Later on, the disease imaging reveals cord atrophy.
Clinical presentation of MS stages
read more and be concise provide good info please
need deep and more reading to finish this section briefly so read the new
references attached.
Microstructural changes in MS
need deep and more reading to finish this section briefly

Mri Animal models
See this article Current developments in MRI for
assessing rodent models of multiple
sclerosis
EAE
TAKE INTO YPUR ACCOUNT THAT WHY WE USE EAE MOUSE MODEL IN PARTICULAR FOR THIS STUDY
ANSWER IN
Article is Establishment and characterization of an optimized mouse model
of multiple sclerosis-induced neuropathic pain using behavioral,
pharmacologic, histologic and immunohistochemical methods

need deep and more reading to finish this section briefly so read the new
references attached.

Clinical diagnosis and assessment of MS in clinical patients
need deep and more reading to finish this section briefly so read the new
references attached.

Conventional Magnetic resonance imaging MRI OVERVIEW AND THE LIMITATION IN DIAGNOSING MS

need deep and more reading to finish this section briefly so read the new
references attached.
Diffusion magnetic resonance imaging DW-MRI
Introduction in DWMRI BASIC PRINCIPL

need deep and more reading to finish this section briefly so read the new
DWI
need deep and more reading to finish this section briefly so read the new
references attached.

Importance OF in DIAGNOSIN MS
need deep and more reading to finish this section briefly
� Diffusion Tensor Imaging DTI
Introduction AND N BASIC PRINCIPL

need deep and more reading to finish this section briefly so read the new
references attached.

Parameters metrics IN GENERAL DEFINITION AND BACKGROUND
AND THEN HOW THESE METRICS CHANGES OF CASE IN MS DISESE
Fractional anisotropy, (FA)
Mean diffusivity (MD
Axial density (AD)
Radical diffusivity (RD)

� Limitation of DTI in MS
particles, any physiologic movement of the same magnitude would interfere with the readings.
� Most recent NOVEL technique NODDI

PLEASE READ ALL ARTICLES ABOUT NNODDI that I have provided to you and summarise each one IN THE FOLLOWING TABLE, THEN WRITE THE
LITERATURE ABOUT IT.

Overview of contemporary research conducted on human OR ANIMAL
IF YOU READ THE REFERENCES YOU WILL KNOW FROM WHICH REFERENCE I DID THE FOLLOWING SUMMARY.

Reference Sample size (n=) Variables measured Techniques used Major findings

58 PD patients and
35 controls
(Human) intracellular volume fraction (Vic), orientation dispersion index (OD), and isotropic volume fraction (Viso) of the basal ganglia Receiver operating characteristic
(ROC) analysis
NODDI ?Vic in the contralateral SNpc and putamen
Vic and OD in the SNpc and putamen showed
significant negative correlations Vic
(P?=?0.0000046) and mean
diffusivity
(P?=?0.019) in the contralateral SNpc were the independent predictors of PD

� CORRELATION AND RELATIONSHIP BETWEEN NODDI AND DTI

Other related References should be used ..no outside references will be accepted in this project

In vivo mapping of human spinal cord microstructure at 300mT/m
Author: Duval, Tanguy

Diffusion Imaging of the Human Spinal Cord and the Vertebral Column
Author: Bammer, Roland

Diffusion MRI (Second Edition)
From Quantitative Measurement to In vivo Neuroanatomy
Edited by: Heidi Johansen-Berg and Timothy E.J. Behrens

Magnetic resonance imaging of myelin
Cornelia Laule , Irene M. Vavasour, Shannon H. Kolind, David K. B. Li, Tony L. Traboulsee, G. R. Wayne Moore, Alex L. MacKay

Neurite orientation dispersion and density imaging of the healthy cervical spinal cord in vivo
Author: Grussu, Francesco

NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain
Author: Zhang, Hui

Demyelination and degeneration in the injured human spinal cord detected with diffusion and magnetization transfer MRI
Author:
Cohen-Adad, J.

Progressive Multiple Sclerosis
Editors: Alastair Wilkins

Minagar, A. 2014, Multiple sclerosis: an overview of clinical features, pathophysiology, neuroimaging, and treatment options, Morgan & Claypool, San Rafael, California

High b-value q-space diffusion-weighted MRI of the human cervical spinal cord in vivo: Feasibility and application to multiple sclerosis
Jonathan A.D. Farrell1,2,3, Seth A. Smith1,2, Eliza M. Gordon-Lipkin4, Daniel S. Reich1,4, Peter A. Calabresi4 andPeter C.M. van Zijl

Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models
Nemat Khan, Maree T. Smith

Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods
Author: Khan, Nemat

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
Cris S Constantinescu, Nasr Farooqi, Kate O’Brien, and Bruno Gran

Hyperalgesia in an animal model of multiple sclerosis
Author: Aicher, Sue A

Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis
Monica Morinia, Luca Roccatagliatab, Raffaella Dell’Evaa, Enrico Pedemonteb, Roberto Furlanc, Simona Minghellid, Debora Giuntib, Ulrich Pfeffera, Monica Marcheseb, Douglas

Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis
Marracci, Gail H

?-Lipoic acid normalizes nociceptive neuronal activity at the spinal cord of diabetic rats
C. Morgado, P. Pereira-Terra andI. Tavares

Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signaling in the dorsal horn of the spinal cord
Nemat Khan1,2, Richard Gordon3, Trent M. Woodruff3 andMaree T. Smith1,2,*

?-Lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-? to ameliorate experimental autoimmune encephalomyelitis in mice
Author:
Wang, Kai-Chen KC

Current developments in MRI for assessing rodent models of multiple sclerosis
Othman I Alomair

In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla
Othman I. Alomair

https://cnx.org/contents/[email protected]:94lv8wHH@4/The-Central-Nervous-System

Spinal diffusion tensor imaging: A comprehensive review with emphasis on spinal cord anatomy and clinical applications
Hendrix, Philipp
Clinically feasible NODDI characterization of glioma using multiband EPI at 7 T
Qiuting Wena, b, Douglas A.C. Kelleyc, Suchandrima Banerjeed, Janine M. Lupob, Susan M. Change, Duan Xub, Christopher P. Hessb, Sarah J. Nelsona, b, f,

Checklist for reporting and reviewing studies of experimental animal models of multiple sclerosis and related disorders
Author: Amor, Sandra

Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE)
Author: Olechowski, Camille J.