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Introduce NSAIDS and side effects, think mostly about cardiovascular side effects. Cover what the direct effects of NSAIDs are – ie COX inhibitors. There is a big debate about whether NSAIDs are deleterious due to COX2 effects in the arteries.
What are the off target effects of NSAIDs? Could they have side effects due to non-COX mediated events? We started investigating via computational chemistry (previous paper sent) – cover this
Describe how antagonism of your nuclear receptor could be linked to CVD (estrogen and progesterone)
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